Seven genomic regions have been found to be highly associated with coeliac disease (Heel, 2008). Genetically predisposed, celiac is a autoimmune disease where the small intestine negatively reacts to specific foods predominantly gluten. Published by nature genetics by David van Heel (Barts and the London School of Medicine and Dentistry, UK) the research has created a stronger argument in inferring that common factors affect a range of autoimmune disorders such as coeliac and type I diabetes.
The strong genetic component is higher than many other diseases. The recent study (last year), in collaboration with colleagues in the UK, David van Heel undertook a study of the disease and identified changes in chromosome 4 increased risk of obtaining celiac disease from a young age(Heel, 2008). The variant has be found to be linked to a wide range of chromosomes. As methods for gene expression analysis are found, the understanding of genetic susceptibility can expand.
Through additional analysis seven regions were found to be highly susceptible to the genetic disorder. Six out of the seven genes were identified as immune control response genes. The identification of these genes furthers knowledge in immune pathways through genetics.
To learn more see website:
http://health.ninemsn.com.au/article.aspx?id=22108
http://www.ncbi.nlm.nih.gov/pubmed/15925839
http://www.hum-molgen.org/NewsGen/03-2008/000008.html
The strong genetic component is higher than many other diseases. The recent study (last year), in collaboration with colleagues in the UK, David van Heel undertook a study of the disease and identified changes in chromosome 4 increased risk of obtaining celiac disease from a young age(Heel, 2008). The variant has be found to be linked to a wide range of chromosomes. As methods for gene expression analysis are found, the understanding of genetic susceptibility can expand.
Through additional analysis seven regions were found to be highly susceptible to the genetic disorder. Six out of the seven genes were identified as immune control response genes. The identification of these genes furthers knowledge in immune pathways through genetics.
To learn more see website:
http://health.ninemsn.com.au/article.aspx?id=22108
http://www.ncbi.nlm.nih.gov/pubmed/15925839
http://www.hum-molgen.org/NewsGen/03-2008/000008.html
Blog By: Kristen Gebala
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